Benchmarking cleavable biotin tags for site-centric chemoproteomics
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Jing Yang
PROVIDER: PXD031019 | iProX | Sun Jan 16 00:00:00 GMT 2022
REPOSITORIES: iProX
Publications
Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics.
Li Zongmin Z Liu Keke K Xu Ping P Yang Jing J
Journal of proteome research 20220425 5
Click chemistry─specifically the copper-catalyzed azide-alkyne cycloaddition─has enabled the development of a wide range of chemical probes to analyze subsets of the functional proteome. The "clickable" proteome can be selectively enriched by using diverse cleavable biotin tags, but the direct identification of probe/tag-modified peptides (or peptide-centric analysis) remains challenging. Here, we evaluated the performance of five commercially available cleavable biotin tags in three most common ...[more]
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