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Proteomic analysis of carbapenem-resistant Klebsiella pneumoniae exposure to tigecycline and aminoglycosides

ABSTRACT: Proteomic analysis of carbapenem-resistant Klebsiella pneumoniae exposure to tigecycline and aminoglycosides

ORGANISM(S): Klebsiella Pneumoniae Subsp. Pneumoniae Hs11286

SUBMITTER: Zhancheng Gao

PROVIDER: PXD031030 | iProX | Mon Jan 17 00:00:00 GMT 2022

REPOSITORIES: iProX

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Proteomics Study of the Synergistic Killing of Tigecycline in Combination With Aminoglycosides Against Carbapenem-Resistant <i>Klebsiella pneumoniae</i>.

Ma Xinqian X Fu Shining S Wang Yifan Y Zhao Lili L Yu Wenyi W He Yukun Y Ni Wentao W Gao Zhancheng Z

Frontiers in cellular and infection microbiology 20220630

Co-administration of antibiotics with synergistic effects is one method to combat carbapenem-resistant organisms. Although the synergistic effects of tigecycline combined with aminoglycosides against carbapenem-resistant Klebsiella pneumoniae (CRKP) have been demonstrated <i>in vitro</i> and in animal models, the underlying mechanism remains elusive. Here we used proteomics analysis to assess the short-term bacterial responses to tigecycline and aminoglycosides alone or in combination. Emergence ...[more]

PMID: 35846751

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