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Proteomic analysis in cataract of Ailuropoda melanoleuca (Giant panda)

ABSTRACT: proteomic analysis between cataract of Ailuropoda melanoleuca (Giant panda) and normal panda

ORGANISM(S): Ailuropoda Melanoleuca

SUBMITTER: Yuyan You

PROVIDER: PXD031039 | iProX | Tue Jan 18 00:00:00 GMT 2022

REPOSITORIES: iProX

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Comparative proteomics in captive giant pandas to identify proteins involved in age-related cataract formation.

You Yuyan Y Bai Chao C Wang Wei W Zhan Tongtong T Hu Xin X Hao Feier F Xia Maohua M Liu Yan Y Ma Tao T Liu Yanhui Y Zheng Changming C Pu Tianchun T Zhang Yizhuo Y Lu Yanping Y Ding Nan N Li Jing J Yin Yanqiang Y Chen Yucun Y Wang Liqin L Zhou Jun J Niu Lili L Xiu Yunfang Y Lu Yan Y Jia Ting T Liu Xuefeng X Zhang Chenglin C

Scientific reports 20230805 1

Approximately 20% of aged captive giant pandas (Ailuropoda melanoleuca) have cataracts that impair their quality of life. To identify potential biomarkers of cataract formation, we carried out a quantitative proteomics analysis of 10 giant pandas to find proteins differing in abundance between healthy and cataract-bearing animals. We identified almost 150 proteins exceeding our threshold for differential abundance, most of which were associated with GO categories related to extracellular localiz ...[more]

PMID: 37543644

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