Dataset Information

Global quantification of glutathione S-transferases in human serum using LC-MS/MS coupled with affinity enrichment

ABSTRACT: The concentrations of glutathione S-transferases (GSTs) in serum are considered disease biomarkers. Members of the GST superfamily often exhibit functional overlap, and can compensate for each other. Global and quantitative evaluation of serum GSTs is therefore urgent, but we currently lack an efficient approach due to technological limitations.

ORGANISM(S): Homo Sapiens

SUBMITTER: Siqi Liu

PROVIDER: PXD031061 | iProX | Wed Jan 19 00:00:00 GMT 2022

REPOSITORIES: iProX

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Publications

Global Quantification of Glutathione S-Transferases in Human Serum Using LC-MS/MS Coupled with Affinity Enrichment.

Zhang Yuxing Y Huang Deliang D Lv Ning N Zhu Guilan G Peng Jinghan J Chou Tiansheng T Zhu Zhibin Z Wang Ju J Chen Yuanyuan Y Fang Xiangdong X Qu Jiuxin J Chen Jun J Liu Siqi S

Journal of proteome research 20220330 5

The members of the glutathione S-transferase (GST) superfamily often exhibit functional overlap and can compensate for each other. Their concentrations in serum are considered as disease biomarkers. A global and quantitative evaluation of serum GSTs is therefore urgent, but there is a lack of efficient approaches due to technological limitations. GSH magnetic beads were examined for their affinity to enrich GSTs in serum, and the enriched GSTs were quantitatively targeted using a Q Exactive HF-X ...[more]

PMID: 35353507

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Dataset Information

Global quantification of glutathione S-transferases in human serum using LC-MS/MS coupled with affinity enrichment

Publications

Global Quantification of Glutathione S-Transferases in Human Serum Using LC-MS/MS Coupled with Affinity Enrichment.

Similar Datasets

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