Proteomics

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Urinary proteomics analysis of active vitiligo patients

ABSTRACT: Vitiligo is a common acquired skin disorder caused by immune-mediated destruction of epidermal melanocytes. Systemic glucocorticoids (GCs) have been used to prevent the progression of active vitiligo, with 8.2%–56.2% of patients insensitive to this therapy. Currently, there is a lack of biomarkers that can accurately predict and evaluate treatment responses. The goal of this study was to identify candidate urinary protein biomarkers to predict the efficacy of GCs treatment in active vitiligo patients and monitor the disease. In the present study, we aimed to identify urinary biomarkers that could predict and monitor the efficacy of steroid treatment. Urine samples were collected from the treatment-resistance group and treatment-effective group before and after GCs treatment and randomly divided into a discovery group and validation group. Differentially expressed proteins were determined using proteomic analysis.

ORGANISM(S): Homo Sapiens

SUBMITTER: Wei Sun  

PROVIDER: PXD031595 | iProX | Fri Feb 11 00:00:00 GMT 2022

REPOSITORIES: iProX

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Urinary Proteomics Analysis of Active Vitiligo Patients: Biomarkers for Steroid Treatment Efficacy Prediction and Monitoring.

Qian Yue-Tong YT   Liu Xiao-Yan XY   Sun Hai-Dan HD   Xu Ji-Yu JY   Sun Jia-Meng JM   Liu Wei W   Chen Tian T   Liu Jia-Wei JW   Tan Yan Y   Sun Wei W   Ma Dong-Lai DL  

Frontiers in molecular biosciences 20220217

Vitiligo is a common acquired skin disorder caused by immune-mediated destruction of epidermal melanocytes. Systemic glucocorticoids (GCs) have been used to prevent the progression of active vitiligo, with 8.2-56.2% of patients insensitive to this therapy. Currently, there is a lack of biomarkers that can accurately predict and evaluate treatment responses. The goal of this study was to identify candidate urinary protein biomarkers to predict the efficacy of GCs treatment in active vitiligo pati  ...[more]

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