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ITRAQ-based Proteome Profiling of Differentially Expressed Proteins in Insulin-resistant Human Hepatocellular Carcinoma

ABSTRACT: Comparison of Proteomics Changes in hepatocellular carcinoma cells and insulin resistant hepatocellular carcinoma cells

ORGANISM(S): Homo Sapiens

SUBMITTER: Linjing Li

PROVIDER: PXD031820 | iProX | Tue Feb 22 00:00:00 GMT 2022

REPOSITORIES: iProX

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iTRAQ-Based Proteome Profiling of Differentially Expressed Proteins in Insulin-Resistant Human Hepatocellular Carcinoma.

Yan Jing J Xie Bei B Tian Ye Y Huang Li L Zou Shuli S Peng Zhiheng Z Liu Zhuan Z Li Linjing L

Frontiers in cell and developmental biology 20220225

Recently, the incidences of insulin resistance (IR) and IR-related complications have increased throughout the world, which also associate with poor prognosis in hepatocellular carcinoma (HCC). Numerous studies had been focused on the role of IR in tumorigenesis and prognosis of HCC. The proteomic analysis of IR related hepatocellular carcinoma had not been reported by now. In the present study, 196 differentially expressed proteins (DEPs) were identified between insulin resistant HepG2 cells an ...[more]

PMID: 35281088

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