Mapping Tyrosine Kinase Based on TK Activity Representing Peptide Library Reveals a Role for SRC in H1975 Drug Resistance
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ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Huadong Liu
PROVIDER: PXD031904 | iProX | Mon Feb 28 00:00:00 GMT 2022
REPOSITORIES: iProX
Publications
Mapping Tyrosine Kinases Based on a TK Activity-Representing Peptide Library Reveals a Role for SRC in H1975 Drug Resistance.
Hou Zhanwu Z Meng Caiting C Yang Fei F Deng Yujiao Y Han Xiao X Liu Huadong H
Journal of proteome research 20220316 4
Tyrosine kinases (TKs) are prominent targets in cancer therapies, and more than 30 TK inhibitors have been approved for treatments in tumors with abnormal TK. Disappointingly, an incomplete response can occur with the long-term use of TK inhibitors, known as cancer drug resistance, which can be caused by kinome reprogramming. Hence, monitoring the status of TKs is crucial for revealing the underlying drug resistance mechanism. Here, we describe a TK activity-representing peptide library-based mu ...[more]
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