ILF3 safeguards telomere from aberrant homologous recombination as a telomeric R-loop reader
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ABSTRACT: Here we found that ILF3 prefers to bind telomere R-loops and protects telomere from aberrant homologous recombination. ILF3 knockout induces TERRA aggregation onto telomere and activates telomere DNA damage response (DDR). Furthermore, ILF3 deficiency disrupts telomere homeostasis and induces abnormal ALT-mediated telomere lengthening
ORGANISM(S): Homo Sapiens
SUBMITTER: Yan Huang
PROVIDER: PXD032093 | iProX | Fri Mar 04 00:00:00 GMT 2022
REPOSITORIES: iProX
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