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Repression of EGLN1 activity by SET7-catalyzed methylation

ABSTRACT: Repression of EGLN1 activity by SET7-catalyzed methylation

ORGANISM(S): Homo Sapiens

SUBMITTER: Wuhan Xiao

PROVIDER: PXD032126 | iProX | Tue Mar 08 00:00:00 GMT 2022

REPOSITORIES: iProX

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EGLN1 prolyl hydroxylation of hypoxia-induced transcription factor HIF1α is repressed by SET7-catalyzed lysine methylation.

Tang Jinhua J Deng Hongyan H Wang Zixuan Z Zha Huangyuan H Liao Qian Q Zhu Chunchun C Chen Xiaoyun X Sun Xueyi X Jia Shuke S Ouyang Gang G Liu Xing X Xiao Wuhan W

The Journal of biological chemistry 20220420 6

Egg-laying defective nine 1 (EGLN1) functions as an oxygen sensor to catalyze prolyl hydroxylation of the transcription factor hypoxia-inducible factor-1 α under normoxia conditions, leading to its proteasomal degradation. Thus, EGLN1 plays a central role in the hypoxia-inducible factor-mediated hypoxia signaling pathway; however, the posttranslational modifications that control EGLN1 function remain largely unknown. Here, we identified that a lysine monomethylase, SET7, catalyzes EGLN1 methylat ...[more]

PMID: 35452683

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