Proteomics

Dataset Information

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Tandem mass tag-mass spectrometry of CCT3 knockdown A549 and H1299 cell lines

ABSTRACT: CCT3 was knocked down in H1299 and A549 cell lines. TMT-MS was employed to detect the differences of intracellular proteins abundance.

ORGANISM(S): Homo Sapiens

SUBMITTER: Yongzhang Luo  

PROVIDER: PXD032248 | iProX | Fri Mar 11 00:00:00 GMT 2022

REPOSITORIES: iProX

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Publications

Suppression of CCT3 Inhibits Tumor Progression by Impairing ATP Production and Cytoplasmic Translation in Lung Adenocarcinoma.

Chen Shuohua S   Tian Yang Y   Ju Anji A   Li Boya B   Fu Yan Y   Luo Yongzhang Y  

International journal of molecular sciences 20220402 7

Heat shock proteins are highly expressed in various cancers and exert critical functions in tumor progression. However, their expression patterns and functions in lung adenocarcinoma (LUAD) remain largely unknown. We identified that chaperonin-containing T-complex protein-1 subunit 3 (CCT3) was highly expressed in LUAD cells and was positively correlated with LUAD malignancy in the clinical samples. Animal studies showed that silencing CCT3 dramatically inhibited tumor growth and metastasis of L  ...[more]