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Proteomic and targeted metabolomic studies on a silkworm model of Parkinson’s disease

ABSTRACT: Proteomic and targeted metabolomic studies on a silkworm model of Parkinson’s disease

ORGANISM(S): Bombyx Mori

SUBMITTER: Keping Chen

PROVIDER: PXD032252 | iProX | Mon Mar 14 00:00:00 GMT 2022

REPOSITORIES: iProX

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Proteomic and Targeted Metabolomic Studies on a Silkworm Model of Parkinson's Disease.

Zhu Feifei F Chen Han H Han Jinying J Zhou Weiwei W Tang Qi Q Yu Qian Q Ma Shangshang S Liu Xiaoyong X Huo Shuhao S Chen Keping K

Journal of proteome research 20220812 9

Parkinson's disease (PD) is a chronic and progressive movement disorder that is characterized by the loss of dopaminergic neurons in the brain. Animal models of PD have become very popular in the past two decades to understand the etiology, pathology, and molecular and cellular pathways associated with PD. In this study, we report the first neurotoxin-induced silkworm model for PD by chronic feeding with 6-hydroxydopamine (6-OHDA) and explore the possible molecular mechanisms associated with PD ...[more]

PMID: 35959672

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