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Integrated proteomic and N-glycoproteomic profiling of placental tissues of patients with preeclampsia

ABSTRACT: Integrated proteomic and N-glycoproteomic profiling of placental tissues of patients with preeclampsia

ORGANISM(S): Homo Sapiens

SUBMITTER: Huijuan Wang

PROVIDER: PXD032286 | iProX | Mon Mar 14 00:00:00 GMT 2022

REPOSITORIES: iProX

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Integrated Proteomic and N-Glycoproteomic Profiling of Placental Tissues of Patients with Preeclampsia.

Wang Huijuan H Shi Yinmin Y Ma Jiying J Wang Wenxia W Gao Jianrong J Zhao Lili L Zhao Ting T Ding Guifeng G

International journal of women's health 20230113

<h4>Background</h4>Preeclampsia (PE) is a multi-system disorder of pregnancy that poses a serious threat to maternal and perinatal health worldwide. This study aims to evaluate the global alterations of protein expression and N-glycosylations that are crucial for PE pathogenesis. Here, tandem mass tag labeling combined with LC-MS/MS was employed to determine the global expression of all proteins and intact glycopeptide in placentas from three healthy pregnant women, three patients with early-ons ...[more]

PMID: 36660462

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