Src heterodimerically activates Lyn or Fyn to serve as targets for esophageal squamous cell carcinoma (ESCC) diagnosis and treatment
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Qimin Zhan
PROVIDER: PXD032306 | iProX | Tue Mar 15 00:00:00 GMT 2022
REPOSITORIES: iProX
Publications
Src heterodimerically activates Lyn or Fyn to serve as targets for the diagnosis and treatment of esophageal squamous cell carcinoma.
Zhang Jing J Zhao Di D Zhang Lingyuan L Xiao Yuanfan Y Wu Qingnan Q Wang Yan Y Chen Jie J Zhan Qimin Q
Science China. Life sciences 20230208 6
Although Src is one of the oldest and most investigated oncoproteins, its function in tumor malignancy remains to be defined further. In this study, we demonstrated that the inhibition of Src activity by ponatinib effectively suppressed several malignant phenotypes of esophageal squamous cell carcinoma (ESCC) both in vitro and in vivo, whereas it did not produce growth-inhibitory effects on normal esophageal epithelial cells (NEECs). Importantly, we combined phosphoproteomics and several cellula ...[more]
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