Src heterodimerically activates Lyn or Fyn to serve as targets for esophageal squamous cell carcinoma (ESCC) diagnosis and treatment

ABSTRACT: we combined phosphoproteomics and several cellular and molecular biologic strategies to identify that Src specifically interacted with the members of Src-family kinases (SFKs), such as Fyn or Lyn to form heterodimers, and subsequently phosphorylate the tyrosine sites in SH2 and kinase domains, which critically contributed to the ESCC malignancy.

ORGANISM(S): Homo Sapiens

SUBMITTER: Qimin Zhan  

PROVIDER: PXD032306 | iProX | Tue Mar 15 00:00:00 GMT 2022

REPOSITORIES: iProX