LC-MS/MS analysis for femoral vein of rat with deep venous thrombosis

ABSTRACT: Secondary pathological changes after vascular injury include all the pathophysiology factors that cause thrombosis. However, this procedure is still complicated and volatile. Discovering new pathological changes associated with trauma and clarifying its mechanism is an important theoretical supplement to the pathology of thrombosis. Iron accumulation significantly accelerates thrombosis after vascular injury. The role of ferroptosis pathway induced by iron overtake in thrombosis was not elucidated. Here, we attempted to answer certain obscure question of the contribution of ferroptosis in DVT and explore its potential mechanism. A total 670 of DEPs involved 330 upregulated proteins and 340 downregulated proteins were identified in DVT group as compared with the control group. Otherwise, compared with DVT group, there were 842 DEPs consisting of 79 upregulated proteins and 763 downregulated proteins in DVTL (DVT+ liproxstatin-1) group. Differences between control, DVT and liproxstatin-1 treatment predominantly affected KEGG pathways of complement/coagulation cascades, glycolysis/ gluconeogenesis, ferroptosis and so on.

ORGANISM(S): Rattus Norvegicus

SUBMITTER: Jianghua Lai  

PROVIDER: PXD032343 | iProX | Thu Mar 17 00:00:00 GMT 2022

REPOSITORIES: iProX