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P.aeruginosa PAO1+Pht Tandem Mass Tag (TMT)-based quantitative proteomic analysis

ABSTRACT: To study the changes in the proteomics profile of P. aeruginosa PAO1 upon Pht addition, TMT was used as the labeling strategy for comparative quantitative proteomic analysis.

ORGANISM(S): Pseudomonas Aeruginosa

SUBMITTER: Liang Yang

PROVIDER: PXD032384 | iProX | Fri Mar 18 00:00:00 GMT 2022

REPOSITORIES: iProX

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The AhR ligand phthiocol and vitamin K analogs as Pseudomonas aeruginosa quorum sensing inhibitors.

Jia Tianyuan T Liu Dongjing D Bi Xianbiao X Li Menglu M Cai Zhao Z Fu Jiapeng J Liu Zhi Z Wu Pengyao P Ke Xue X Jia Aiqun A Zhang Guoliang G Li Guobao G Yang Liang L

Frontiers in microbiology 20220914

The aryl hydrocarbon receptor (AhR) protein senses microbial-secreted metabolites to trigger the host's innate immune system. The Pseudomonas quinolone signal (PQS) and Mycobacterium tuberculosis (MTb) metabolite phthiocol (Pht) are both ligands of AhR with similar chemical structures. As PQS is an essential quorum-sensing molecule that regulates a wide range of virulence factors in Pseudomonas aeruginosa, we hypothesized that Pht and its analogs are potential P. aerugino ...[more]

PMID: 36187967

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