Proteomic Profile Analysis of Simple steatosis and Non-alcoholic Steatohepatitis in Mice
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ABSTRACT:
ORGANISM(S): Mus Musculus Mus <genus>
SUBMITTER: 
Yan Lu
PROVIDER: PXD032806 | iProX | Thu Mar 24 00:00:00 GMT 2022
REPOSITORIES: iProX
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Project description:In our study, C57BL/6 male mice were fed a normal chow diet or high-fat diet additionally containing high-fructose and high-cholesterol (HFHC diet) for 12 weeks and 28 weeks to construct simple steatosis (NAFL) and Non-alcoholic steatohepatitis (NASH) models respectively. Through miRNA sequencing, 420 miRNAs were detected. A total of 148 miRNAs (14 up-regulated and 34 down-regulated) and 146 miRNAs (74 up-regulated and 72 down-regulated) were differentially expressed in livers of NAFL and NASH mice, respectively. A total of 36 miRNAs (8 up-regulated; 28 down-regulated) were dysregulated in both NASH and NAFL mice, while 110 miRNAs (66 up-regulated; 44 down-regulated) were altered specifically in NASH mice.
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