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FOXN3 affinity-purification-Mass spectrometry

ABSTRACT: Affinity-purified FOXN3 was subjected to mass spectrometry analysis.

ORGANISM(S): Homo Sapiens

SUBMITTER: Xinxing Zhu

PROVIDER: PXD032864 | iProX | Mon Mar 28 00:00:00 BST 2022

REPOSITORIES: iProX

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p38-mediated FOXN3 phosphorylation modulates lung inflammation and injury through the NF-κB signaling pathway.

Zhu Xinxing X Huang Beijia B Zhao Fengting F Lian Jie J He Lixiang L Zhang Yangxia Y Ji Longkai L Zhang Jinghang J Yan Xin X Zeng Taoling T Ma Chunya C Liang Yinming Y Zhang Chen C Lin Juntang J

Nucleic acids research 20230301 5

NF-κB activates the primary inflammatory response pathway responsible for methicillin-resistant Staphylococcus aureus (MRSA)-induced lung inflammation and injury. Here, we report that the Forkhead box transcription factor FOXN3 ameliorates MRSA-induced pulmonary inflammatory injury by inactivating NF-κB signaling. FOXN3 competes with IκBα for binding to heterogeneous ribonucleoprotein-U (hnRNPU), thereby blocking β-TrCP-mediated IκBα degradation and leading to NF-κB inactivation. FOXN3 is direct ...[more]

PMID: 36794705

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