Proteomics

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Re-innervation muscle in nerve crush rats


ABSTRACT: Two simulated nerve injury models in the rat tibial nerve were compared: the nerve was either cut (denervated, DN group) or crushed but with the nerve sheath intact (re-innervated, RN group). The control group had a preserved and intact tibial nerve. As the high expression of Myh3, Postn, Col6a1 and Cfi (nerve growth factors), the RN group demonstrated superior re-innervation as well. Both differentially expressed genes (DEGs) and proteins (DEPs) were enriched in the PPAR signaling pathway, as well as the energy metabolism.

ORGANISM(S): Rattus Rattus

SUBMITTER: Haotao Li  

PROVIDER: PXD033031 | iProX | Wed Apr 06 00:00:00 BST 2022

REPOSITORIES: iProX

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Publications

Transcription and proteome changes involved in re-innervation muscle following nerve crush in rats.

Li Haotao H   Yuan Wanqiong W   Chen Yijian Y   Lin Bofu B   Wang Shuai S   Deng Zhantao Z   Zheng Qiujian Q   Li Qingtian Q  

BMC genomics 20220922 1


Severe peripheral nerve injury leads to the irreparable disruption of nerve fibers. This leads to disruption of synapses with the designated muscle, which consequently go through progressive atrophy and damage of muscle function. The molecular mechanism that underlies the re-innervation process has yet to be evaluated using proteomics or transcriptomics. In the present study, multi-dimensional data were therefore integrated with transcriptome and proteome profiles in order to investigate the mec  ...[more]

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