Dataset Information
RNA Pull-Down identifies the interactive proteins with tRF-Gln-CTG-026 in HL-7702 and AML12 cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens Mus Musculus
SUBMITTER: 
Qi Zhou
PROVIDER: PXD033097 | iProX | Fri Apr 08 00:00:00 BST 2022
REPOSITORIES: iProX
Publications
tRF-Gln-CTG-026 ameliorates liver injury by alleviating global protein synthesis.
Signal transduction and targeted therapy 20230403 1
tsRNAs (tRNA-derived small RNAs), as products of the stress response, exert considerable influence on stress response and injury regulation. However, it remains largely unclear whether tsRNAs can ameliorate liver injury. Here, we demonstrate the roles of tsRNAs in alleviating liver injury by utilizing the loss of NSun2 (NOP2/Sun domain family, member 2) as a tsRNAs-generating model. Mechanistically, the loss of NSun2 reduces methyluridine-U5 (m<sup>5</sup>U) and cytosine-C5 (m<sup>5</sup>C) of t ...[more]
