Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus
SUBMITTER: Suren Chen
PROVIDER: PXD033133 | iProX | Mon Apr 11 00:00:00 BST 2022
REPOSITORIES: iProX
EBioMedicine 20230621
<h4>Background</h4>Male infertility is a worldwide population health concern, but its aetiology remains largely understood. Although CFAP70 variants have already been reported in two oligo-astheno-teratozoospermia (OAT) individuals by sequencing, animal evidence to support CFAP70 as a credible OAT-pathogenic gene is lacking.<h4>Method</h4>Cfap70-KO mice were generated to explore the physiological role of CFAP70. CFAP70 variants were detected in infertile men with OAT by whole exome sequencing an ...[more]