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Polygonum perfoliatum L. ameliorates NAFLD by promoting PPARs/CPT1A/CPT2-mediated fatty acid β-oxidation

ABSTRACT: We performed a label-free quantitative proteomic profiling to determine the effect of Polygonum perfoliatum L. treated the proteomics profile of liver tissue and identified activated PPARs/CPT1A/CPT2-mediated hepatic fatty acid β oxidation process was significantly altered

ORGANISM(S): Mus Musculus

SUBMITTER: Xiaoni Kong

PROVIDER: PXD033219 | iProX | Mon Feb 05 00:00:00 GMT 2024

REPOSITORIES: iProX

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Quantitative proteomics reveals <i>Polygonum perfoliatum L.</i> ameliorates hepatic steatosis by promoting PPARs/CPT1A/CPT2-mediated fatty acid β-oxidation.

Liu Guanjie G Chang Ling L Qian Yihan Y Lin Jiacheng J Shang Zhi Z Xu Min M Wang Fang F Sun Xuehua X Jiang Yun Y Gao Yueqiu Y Kong Xiaoni X

Frontiers in pharmacology 20230323

Non-alcoholic fatty liver disease (NAFLD) is a predominant contributor to end-stage liver disease in the forthcoming decades. <i>Polygonum perfoliatum L.</i> (PPL) is an herbal medicine with anti-lipid peroxidation and anti-inflammatory properties. However, detailed hepatoprotective effects of PPL against NAFLD and its underlying mechanisms are not fully understood. Here, we found that PPL protects against high fat diet (HFD)-induced hepatic steatosis, lipid peroxidation, and glucose-lipid metab ...[more]

PMID: 37033635

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