Icariside II restores vascular smooth muscle cell contractile phenotype by enhancing focal adhesion signaling pathway in rat vascular remodeling model

ABSTRACT: In this work, we investigated the pharmacological effects of ICS-II on VSMC phenotypic transition and reveal the underlying mechanisms through in vivo and in vitro experiments. Our results highlight the thera-peutic benefits of ICS-II targeting VSMC phenotypic transition and sup-port the potential of pharmacological strategies in CVD management.

ORGANISM(S): Rattus Norvegicus

SUBMITTER: Hao Wen  

PROVIDER: PXD033724 | iProX | Thu May 05 00:00:00 BST 2022

REPOSITORIES: iProX