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Astrocyte, OPC, OL in rat postnatal development

ABSTRACT: Proteomic analysis of astrocyte, OPC, OL isolated from postnatal day 5 rat.

ORGANISM(S): Rattus Norvegicus

SUBMITTER: Jianqin Niu

PROVIDER: PXD033729 | iProX | Tue May 03 00:00:00 BST 2022

REPOSITORIES: iProX

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Astrocyte endfoot formation controls the termination of oligodendrocyte precursor cell perivascular migration during development.

Su Yixun Y Wang Xiaorui X Yang Yujian Y Chen Liang L Xia Wenlong W Hoi Kimberly K KK Li Hui H Wang Qi Q Yu Guangdan G Chen Xiaoying X Wang Shouyu S Wang Yuxin Y Xiao Lan L Verkhratsky Alexei A Fancy Stephen P J SPJ Yi Chenju C Niu Jianqin J

Neuron 20221115 2

Oligodendrocyte precursor cells (OPCs) undergo an extensive and coordinated migration in the developing CNS, using the pre-formed scaffold of developed blood vessels as their physical substrate for migration. While OPC association with vasculature is critical for dispersal, equally important for permitting differentiation and proper myelination of target axons is their appropriate and timely detachment, but regulation of this process remains unclear. Here we demonstrate a correlation between the ...[more]

PMID: 36384142

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