The proteome data of human mesenchymal stem cell derived from healthy donors
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Lei Zhang
PROVIDER: PXD033812 | iProX | Mon Jun 12 00:00:00 BST 2023
REPOSITORIES: iProX
Publications
Multi-omics analysis of human mesenchymal stem cells shows cell aging that alters immunomodulatory activity through the downregulation of PD-L1.
Gao Yuchen Y Chi Ying Y Chen Yunfei Y Wang Wentian W Li Huiyuan H Zheng Wenting W Zhu Ping P An Jinying J Duan Yanan Y Sun Ting T Liu Xiaofan X Xue Feng F Liu Wei W Fu Rongfeng R Han Zhibo Z Zhang Yingchi Y Yang Renchi R Cheng Tao T Wei Jun J Zhang Lei L Zhang Xiaomin X
Nature communications 20230720 1
Mesenchymal stem cells (MSCs) possess potent immunomodulatory activity and have been extensively investigated for their therapeutic potential in treating inflammatory disorders. However, the mechanisms underlying the immunosuppressive function of MSCs are not fully understood, hindering the development of standardized MSC-based therapies for clinical use. In this study, we profile the single-cell transcriptomes of MSCs isolated from adipose tissue (AD), bone marrow (BM), placental chorionic memb ...[more]
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