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Comparative proteomic and clinicopathlogical analysis of breast adenoid cystic carcinoma and basal-like triple-negative breast cancer

ABSTRACT: We applied mass spectrometry-based quantitative proteomics to analyze the protein expression in paired tumor and adjacent normal breast tissue of five ACC and five BL-TNBC. Bioinformatic analyses and the clinicopathological information including histologic features, immunohistochemistry and FISH were also conducted to get the comprehensive information.

ORGANISM(S): Homo Sapiens

SUBMITTER: Qian Yao

PROVIDER: PXD033928 | iProX | Mon May 16 00:00:00 BST 2022

REPOSITORIES: iProX

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Comparative proteomic and clinicopathological analysis of breast adenoid cystic carcinoma and basal-like triple-negative breast cancer.

Yao Qian Q Hou Wei W Chen Junbing J Bai Yanhua Y Long Mengping M Huang Xiaozheng X Zhao Chen C Zhou Lixin L Niu Dongfeng D

Frontiers in medicine 20220728

<h4>Background</h4>Adenoid cystic carcinoma (ACC) is a rare type of triple-negative breast cancer that has an indolent clinical behavior. Given the substantial overlapping morphological, immunohistochemical, and molecular features with other basal-like triple-negative breast cancer (BL-TNBC), accurate diagnosis of ACC is crucial for effective clinical treatment. The integrative analysis of the proteome and clinicopathological characteristics may help to distinguish these two neoplasms and provid ...[more]

PMID: 35966872

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