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Cardiomyocyte-Specific Calsyntenin-1 Overexpression in Dilated Cardiomyopathy Rats

ABSTRACT: In order to explore the underlying pathogenic role of Calsyntenin-1(CLSTN1) in dilated cardiomyopathy (DCM), we constructed cardiomyocyte-specific CLSTN1 overexpression (CLSTN1-OE) rats and a cumulative dose of 18 mg/kg doxorubicin were injected to induce DCM. Whole heart tissues from the Con-WT(n=4), Con-CLSTN1 OE(n=3), DCM-WT(n=3), and DCM-CLSTN1 OE(n=4) were collected for proteomics analysis via a QExactive mass spectrometer.

ORGANISM(S): Rattus Norvegicus

SUBMITTER: Kunlun He

PROVIDER: PXD033929 | iProX | Mon May 16 00:00:00 BST 2022

REPOSITORIES: iProX

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