Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus
SUBMITTER: Qiurong Ding
PROVIDER: PXD034125 | iProX | Wed May 25 00:00:00 BST 2022
REPOSITORIES: iProX
Zhao Yongxu Y Li Shuang S Chen Yanhao Y Wang Yuchen Y Wei Yuda Y Zhou Tingting T Zhang Yuwei Y Yang Yuanyuan Y Chen Lanlan L Liu Yan Y Hu Cheng C Zhou Ben B Ding Qiurong Q
Molecular cell 20230301 7
The glucagon-PKA signal is generally believed to control hepatic gluconeogenesis via the CREB transcription factor. Here we uncovered a distinct function of this signal in directly stimulating histone phosphorylation for gluconeogenic gene regulation in mice. In the fasting state, CREB recruited activated PKA to regions near gluconeogenic genes, where PKA phosphorylated histone H3 serine 28 (H3S28ph). H3S28ph, recognized by 14-3-3ζ, promoted recruitment of RNA polymerase II and transcriptional s ...[more]