Proteomics

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The eWAT ubiquitinome of wild type mice and Mdm2 adipocyte-specific knock-in mice fed high-fat diet

ABSTRACT: The epididymal adipose tissue (eWAT) samples from wild type mice fed high-fat diet for 12 weeks (H_WT_E) and Mdm2 adipocyte-specific knock-in mice fed high-fat diet for 12 weeks (H_KI_E) were mixed separately, and subjected to ubiquitinome study by Label-free quantification and ubiquitination modification enrichment techniques, etc. The proteomics of mixed eWAT samples were performed in Jingjie PTM BioLab (Hangzhou) Co. Ltd (www.ptm-biolab.com.cn). The difference was determined by 1.5-fold-change criterion, FDR < 0.01.

ORGANISM(S): Mus Musculus

SUBMITTER: Prof. Xiaojun Liu  

PROVIDER: PXD034127 | iProX | Thu May 26 00:00:00 BST 2022

REPOSITORIES: iProX

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Publications

Murine double minute 2 aggravates adipose tissue dysfunction through ubiquitin-mediated six-transmembrane epithelial antigen of prostate 4 degradation.

Zhao Wei W   Xu Qiang Q   Yang Jiahui J   Xie Xianghong X   Li Chunmei C   Zhang Weihong W   Chen Enhui E   Guo Yanfang Y   Gao Mingyue M   Shi Jie J   Zhang Huabing H   Yao Hong H   Li Meixia M   Yan Li L   Fang Fude F   Wu Wenming W   Liu Xiaojun X  

iScience 20220607 7

Healthy adipose tissue is crucial to maintain normal energy homeostasis. Little is known about the role of murine double minute 2 (MDM2), an E3 ubiquitin ligase and has been highlighted in oncopathology, in adipose tissue. Our results indicated that MDM2 expression was associated with nutritional status. <i>Mdm2</i> adipocyte-specific knock-in (<i>Mdm2</i>-AKI) mice exhibited exacerbated weight gain, insulin resistance, and decreased energy expenditure. Meanwhile, chronic high-fat diet (HFD) exp  ...[more]

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