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Mouse Cardiac Proteomics and β-hydroxybutyrylation omics Studies

ABSTRACT: β-Hydroxybutyrylation (kbhb) is a new type of post-translational modification(PTM) of lysine acylation. In recent years, kbhb modification has been shown to be involved in energy metabolism, tumor metabolism, DNA damage repair and other processes. Currently, lysine β-hydroxybutyrylation has not been studied in cardiac tissue. In this study, we performed proteomic and β-hydroxybutyrylation modification omics analysis of mouse heart tissue based on LC-MS/MS analysis. These data provide the first mammalian cardiac kbhb dataset and provide new directions for further investigation of the function of kbhb in non-histone proteins.

ORGANISM(S): Mus Musculus

SUBMITTER: Yanqiu Xing

PROVIDER: PXD034269 | iProX | Tue Mar 14 00:00:00 GMT 2023

REPOSITORIES: iProX

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Quantification and Proteomic Characterization of β-Hydroxybutyrylation Modification in the Hearts of AMPKα2 Knockout Mice.

Ding Wen-Jing WJ Li Xue-Hui XH Tang Cong-Min CM Yang Xue-Chun XC Sun Yan Y Song Yi-Ping YP Ling Ming-Ying MY Yan Rong R Gao Hai-Qing HQ Zhang Wen-Hua WH Yu Na N Feng Jun-Chao JC Zhang Zhen Z Xing Yan-Qiu YQ

Molecular & cellular proteomics : MCP 20230105 2

AMP-activated protein kinase alpha 2 (AMPKα2) regulates energy metabolism, protein synthesis, and glucolipid metabolism myocardial cells. Ketone bodies produced by fatty acid β-oxidation, especially β-hydroxybutyrate, are fatty energy-supplying substances for the heart, brain, and other organs during fasting and long-term exercise. They also regulate metabolic signaling for multiple cellular functions. Lysine β-hydroxybutyrylation (Kbhb) is a β-hydroxybutyrate-mediated protein posttranslational ...[more]

PMID: 36621768

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