Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Proteomic analysis of the primo vascular system in rabbits

ABSTRACT: In this study, to elucidate the character of primo vascular system (PVS) in inflammation, we harvested all PVS tissues from the abdominal cavity of rabbits in Cecitis and Control groups at day 7, and performed TMT-based quantitative proteomic analysis

ORGANISM(S): Oryctolagus Cuniculus

SUBMITTER: Yi Ding

PROVIDER: PXD034280 | iProX | Thu Jun 02 00:00:00 BST 2022

REPOSITORIES: iProX

ACCESS DATA

Json Xml

Publications

The involvement of the primo vascular system in local enteritis and its modification by electroacupuncture.

Nan Sha S Wan Juan J Lei Qianghui Q Wang Xinya X Ma Ning N Yin Ruiling R Zhu Jiandi J Ding Mingxing M Ding Yi Y

Frontiers in immunology 20230111

<h4>Introduction</h4>The primo vascular system (PVS), an intensive network structure, has been claimed to be representative of the acupuncture meridian. Here, we explored the role of the PVS in local enteritis and its modification by acupuncture.<h4>Methods</h4>Chronic cecitis in rabbits was induced by 2,4,6-trinitro-benzene-sulfonic acid (TNBS). The PVS on the cecum was visualized with trypan blue staining, and collected with the help of microsurgical forceps under an optical stereomicroscope.< ...[more]

PMID: 36713388

Similar Datasets

BAF60a Deficiency in Vascular Smooth Muscle Cells Prevents Abdominal Aortic Aneurysm Formation by Attenuating Vascular Inflammation

Project description:BAF60a Deficiency in Vascular Smooth Muscle Cells Prevents Abdominal Aortic Aneurysm Formation by Attenuating Vascular Inflammation

| PRJNA642734 | ENA

PRDM16 Deficiency in Vascular Smooth Muscle Cells Aggravates Abdominal Aortic Aneurysm

Project description:Abdominal aortic aneurysm (AAA) is usually asymptomatic until life-threatening complications occur, predominantly involving aortic rupture. Currently, no drug-based treatments are available, primarily due to limited understanding of AAA pathogenesis. The transcriptional regulator PR domain–containing protein 16 (PRDM16) is highly expressed in the aorta, but its functions in the aorta are largely unknown. By RNA-seq analysis, we found that vascular smooth muscle cell–specific (VSMC-specific) Prdm16-knockout (Prdm16SMKO) mice already showed extensive changes in the expression of genes associated with extracellular matrix (ECM) remodeling and inflammation in the abdominal aorta under normal housing conditions without any pathological stimuli. Human AAA lesions displayed lower PRDM16 expression. Periadventitial elastase application to the suprarenal region of the abdominal aorta aggravated AAA formation in Prdm16SMKO mice. During AAA development, VSMCs undergo apoptosis because of both intrinsic and environmental changes, including inflammation and ECM remodeling. Prdm16 deficiency promoted inflammation and apoptosis in VSMCs. A disintegrin and metalloproteinase 12 (ADAM12) is a gelatinase that can degrade various ECMs. We found that ADAM12 is a target of transcriptional repression by PRDM16. Adam12 knockdown reversed VSMC apoptosis induced by Prdm16 deficiency. Our study demonstrated that PRDM16 deficiency in VSMCs promoted ADAM12 expression and aggravates AAA formation, which may provide potential targets for AAA treatment.

2023-06-08 | GSE222440 | GEO

Targeting of lncRNA Morrbid inhibits abdominal aortic aneurysm by regulating macrophage-mediated vascular inflammation.

Project description:Targeting of lncRNA Morrbid inhibits abdominal aortic aneurysm by regulating macrophage-mediated vascular inflammation.

| PRJNA957760 | ENA

Hepatectomy sham surgery 1h

Project description:4 Adult male Sprague-Dawley rats (275-350 g) were anesthetized and subjected to hepatectomy sham surgery (abdominal cavity was opened, liver was handled, but no tissue resection was made). 1 hour after the surgery rats were killed and liver samples were harvested. This study was conducted to analyzes the effects of surgical stress on gene expression levels in rat liver. It provides additional data to 1-6 h partial hepatectomy study (Series GSE7415). Keywords: 1h hepatectomy sham surgery

2007-09-26 | GSE9137 | GEO

Vascular remodeling following pulmonary hypertension

Project description:Hypoxia can induce vasoconstriction followed by vascular remodeling including hypertrophy and hyperplasia of pulmonary vascular smooth muscle and proliferation of endothelial cells. The goal of this project is to elucidate the genes involved in vascular remodeling following pulmonary hypertension. Total RNA was isolated from lungs of normoxic and hypoxic treated animals. Keywords: other

2003-07-16 | GSE482 | GEO

Endothelial IGFBP6 Suppresses Vascular Inflammation and Atherosclerosis

Project description:Endothelial IGFBP6 Suppresses Vascular Inflammation and Atherosclerosis

| PRJNA1104204 | ENA

PARP15 promotes vascular barrier integrity in inflammation

Project description:PARP15 promotes vascular barrier integrity in inflammation

| PRJNA989163 | ENA

Tetraspanin-enriched Membrane Domains Regulate Vascular Leakage by Membrane Cholesterol Accessibility to Balance Antagonistic GTPases.

Project description:As an endothelium destabilizer, CD82 facilitates vascular leakage by disrupting endothelial barrier and inhibiting its recovery during inflammation. AC at EC surface primes and promotes vascular leakage, mediates the effect of CD82 or TEMD on inflammation, and can be regulated specifically by i) tetraspanins or TEMDs, ii) ORP-mediated transfer of cholesterol, iii) environmental cholesterol, and iv) statin. Thus, tetraspanin-AC interaction and subcellular cholesterol compartmentalization tune the balances between antagonistic signaling axes of Cdc42 versus RhoA, to alter vascular leakage in inflammation. Equally important, we demonstrated anti-vascular leakage and anti-inflammation roles of i) AC reduction and ii) FARP1-Cdc42 elevation/activation in animal models, with promising translational and clinical prospects.

2025-06-19 | PXD065001 | Pride

DNA methylation regulates lineage-specifying genes in the human vascular system.

Project description:This SuperSeries is composed of the following subset Series: GSE32709: DNA methylation regulates lineage-specifying genes in the human vascular system [expression array]. GSE34486: DNA methylation regulates lineage-specifying genes in the human vascular system [methylation array]. Refer to individual Series

2012-04-09 | E-GEOD-34487 | biostudies-arrayexpress

Proteomic Profiling Exosomes from Vascular Smooth Muscle Cell

Project description:The components of the exosomes are essential to understand how vascular smooth muscle cells (VSMC) and endothelial cells communicate with each other. Exosomes secreted by human VSMCs were harvested and analyzed by nanoLC-MS/MS. The activity of the identified proteins were further assessed by the in vivo matrigel plug angiogenesis assay.

2018-05-07 | PXD007707 | Pride

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data