Proteomics

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Proteomic profiling of the kidney tissue scaffold from normal and fibrotic kidneys


ABSTRACT: The proteomic profiling of the kidney tissue scaffold derived from normal and fibrotic kidneys was carried out by an unbiased LC-MS/MS approach.

ORGANISM(S): Mus <genus>

SUBMITTER: Youhua Liu  

PROVIDER: PXD034281 | iProX | Wed Mar 15 00:00:00 GMT 2023

REPOSITORIES: iProX

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Publications

Proteomic landscape of the extracellular matrix in the fibrotic kidney.

Li Li L   He Meizhi M   Tang Xiaoman X   Huang Junxin J   Li Jing J   Hong Xue X   Fu Haiyan H   Liu Youhua Y  

Kidney international 20230217 6


The extracellular matrix (ECM) is a complex three-dimensional network of proteins surrounding cells, forming a niche that controls cell adhesion, proliferation, migration and differentiation. The ECM network provides an architectural scaffold for surrounding cells and undergoes dynamic changes in composition and contents during the evolution of chronic kidney disease (CKD). Here, we unveiled the proteomic landscape of the ECM by delineating proteome-wide and ECM-specific alterations in normal an  ...[more]

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