Ontology highlight
ABSTRACT:
ORGANISM(S): Mus <genus>
SUBMITTER: Yun-Chi Tang
PROVIDER: PXD034339 | iProX | Mon Jun 06 00:00:00 BST 2022
REPOSITORIES: iProX
Communications biology 20220728 1
Circadian dysregulation associates with numerous diseases including metabolic dysfunction, sleep disorder, depression and aging. Given that declined circadian amplitude is a trait commonly found with compromised health, interventions that design in precluding circadian amplitude from dampening will aid to mitigate complex, circadian-related diseases. Here we identify a neurogenic small molecule ISX-9 that is able to support persistent and higher amplitude of circadian oscillations. ISX-9 improve ...[more]