Dataset Information

Effect of selenium treatment on central insulin sensitivity: a proteomic analysis in APP/PS1 transgenic mice

ABSTRACT: Prior studies have demonstrated a closed association between brain insulin resistance and Alzheimer’s disease (AD), while selenium supplementation was shown to improve insulin homeostasis in AD patients and to exert neuroprotective effects in a mouse model of AD. But the mechanisms underlying the neuroprotective actions of selenium remain incompletely understood. In this study we performed a label-free LC-MS/MS quantitative proteomics approach to analyze differentially expressed proteins (DEPs) in the hippocampus and cerebral cortex of APP/PS1 mice following 2 months of treatment with sodium selenate.

ORGANISM(S): Mus Musculus

SUBMITTER: Wenxiu Sun

PROVIDER: PXD034613 | iProX | Thu Jun 16 00:00:00 BST 2022

REPOSITORIES: iProX

ACCESS DATA

Publications

Effect of Selenium Treatment on Central Insulin Sensitivity: A Proteomic Analysis in β-Amyloid Precursor Protein/Presenilin-1 Transgenic Mice.

Xu Xia X Qi Pishui P Zhang Ying Y Sun Huihuan H Yan Yong Y Sun Wenxiu W Liu Shudong S

Frontiers in molecular neuroscience 20220707

Prior studies have demonstrated a close association between brain insulin resistance and Alzheimer's disease (AD), while selenium supplementation was shown to improve insulin homeostasis in AD patients and to exert neuroprotective effects in a mouse model of AD. However, the mechanisms underlying the neuroprotective actions of selenium remain incompletely understood. In this study, we performed a label-free liquid chromatography-tandem mass spectrometry (LC-MS/MS) quantitative proteomics approac ...[more]

PMID: 35875664

Similar Datasets

Project description:Background: Thiazolidinediones (TZDs) activate peroxisome proliferator-activated receptor gamma (PPARgamma) and are used clinically to help restore peripheral insulin sensitivity in Type 2 diabetes (T2DM). Interestingly, long-term treatment of mouse models of Alzheimer’s disease (AD) with TZDs also has been shown to reduce several well-established brain biomarkers of AD including inflammation, oxidative stress and Abeta accumulation. While some of the TZD actions are becoming clear in AD models and may mediate their reported beneficial impact in AD patients, little is known about the functional consequences of TZDs in animal models of normal aging. Because aging is a common risk factor for both AD and T2DM, we investigated whether the TZD, pioglitazone could alter brain aging under non-pathological conditions. Findings: The TZD pioglitazone (PIO) was incorporated into the diet to yield a final dose of approximately 2.3 mg/kg body weight/day. PIO reduced insulin levels irrespective of age. Interestingly, a significant reduction in the Ca2+-dependent afterhyperpolarization was seen in the aged animals with no significant change in LTP maintenance or learning and memory performance. Finally, a combination of microarray analyses on hippocampal tissue and serum-based multiplex cytokine assays revealed that age-dependent inflammatory changes in brain and periphery were not reversed by PIO. Conclusions: While current research efforts continue to address the underlying processes responsible for the progressive decline in cognitive function seen during aging, available medical treatments are still very limited. Our study, therefore, was aimed at elucidating potentially novel actions of TZDs in the aging brain. Using a clinically-relevant dose and delivery method, PIO had no detectable impact on several indices of brain aging and failed to alter both peripheral and central age-related increases in inflammatory signaling. Keywords: hippocampus, rat, young or aged, control or pioglitazone-treated

Dataset Information

Effect of selenium treatment on central insulin sensitivity: a proteomic analysis in APP/PS1 transgenic mice

Publications

Effect of Selenium Treatment on Central Insulin Sensitivity: A Proteomic Analysis in β-Amyloid Precursor Protein/Presenilin-1 Transgenic Mice.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets