Aspirin-acetylated SIRT1 induces apoptosis and modulates healthy aging
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ABSTRACT: Aspirin or cellular acetyl-CoA could directly acetylate proteins to affect diversity functions. We identify HDACs could be the directly acetylated substrates of aspirin. The inside functional lysine of SIRT1 could be acetylated by aspirin or acetyl-CoA but not be deacetylated by active SIRT1. This irreversible acetylation of SIRT1 inhibits its activity and regulates healthy aging in C. elegans.
ORGANISM(S): Homo Sapiens
SUBMITTER: Wei Yu
PROVIDER: PXD034711 | iProX | Mon Jun 20 00:00:00 BST 2022
REPOSITORIES: iProX
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