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Deep coverage proteome analysis of hair shaft for forensic individual identification

ABSTRACT: Hair shaft is one of the most common biological evidences found at crime scene. Due to the low amount and high degradation of nuclear DNA in hair shaft, it is difficult to achieve individual identification through routine method. The proteins in the hair shaft are stable and contain genetic polymorphisms in the form of single amino acid polymorphisms (SAPs), translated from non-synonymous single nucleotide polymorphisms (nsSNPs) in the genome.

ORGANISM(S): Homo Sapiens

SUBMITTER: Lei Feng

PROVIDER: PXD034814 | iProX | Wed Jun 22 00:00:00 BST 2022

REPOSITORIES: iProX

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Deep coverage proteome analysis of hair shaft for forensic individual identification.

Wu Jialei J Liu Jianhui J Ji Anquan A Ding Dongsheng D Wang Guiqiang G Liu Yao Y Zhang Lihua L Feng Lei L Ye Jian J

Forensic science international. Genetics 20220618

Hair shaft is one of the most common biological evidence found at crime scenes. However, due to the biogenic degradation of nuclear DNA in hair shaft, it is difficult to achieve individual identification through routine DNA analysis. In contrast, the proteins in hair shaft are stable and contain genetic polymorphisms in the form of single amino acid polymorphisms (SAPs), translated from non-synonymous single nucleotide polymorphisms (nsSNPs) in the genome. However, the number of SAPs detected st ...[more]

PMID: 35772265

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