Dataset Information

Synthesis, Insecticidal Activities and Mode of Action of Novel Imidazopyridine Mesoionic Derivatives Containing an Amido group

ABSTRACT: KEGG enrichment analysis showed that the proteins which differentially expressed between the control and C6-treated groups are mainly enriched in pathways of neurodegeneration (ko05022), amyotrophic lateral sclerosis (ko05014), prion disease (ko05020), parkinson disease (ko05012) and huntington disease (ko05016). These pathways are all related to the nervous system, and associated with mitochondrial dysfunction, oxidative stress, and axonal dysfunction. The above results suggested that compound C6 may have effects on the nervous system of A. craccivora.

ORGANISM(S): Aphis Craccivora

SUBMITTER: Zhengjun Liu

PROVIDER: PXD034928 | iProX | Mon Jun 27 00:00:00 BST 2022

REPOSITORIES: iProX

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Synthesis, insecticidal activity, and mode of action of novel imidazopyridine mesoionic derivatives containing an amido group.

Liu Zhengjun Z Song Runjiang R Zhang Desheng D Wu Rong R Liu Ting T Wu Zhengxue Z Zhang Jian J Hu Deyu D

Pest management science 20220829 11

<h4>Background</h4>In our previous work, we applied a new synthetic strategy to design and synthesize a series of imidazopyridine mesoionic derivatives with an ester group. The newly synthesized compounds had excellent insecticidal activity against aphids; however, insecticidal activity against planthoppers was less than satisfactory. In the present study, we designed and synthesized a series of novel imidazopyridine mesoionic compounds, containing an amido group, and these compounds were found ...[more]

PMID: 36054072

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Project description:Neurodegenerative diseases of the central nervous system are characterised by pathogenetic cellular and molecular changes in specific areas of the brain that lead to the dysfunction and/or loss of explicit neuronal populations. Despite exhibiting different clinical profiles and selective neuronal loss, common features such as abnormal protein deposition, dysfunctional cellular transport, mitochondrial deficits, glutamate excitotoxicity and inflammation are observed in most, if not all, neurodegenerative disorders, suggesting converging pathways of neurodegeneration. We have generated comparative genome-wide gene expression data for Alzheimer’s disease, amyotrophic lateral sclerosis, Huntington’s disease, multiple sclerosis, Parkinson’s disease and schizophrenia using an extensive cohort of well characterised post-mortem CNS tissues. The analysis of whole genome expression patterns across these major disorders offers an outstanding opportunity not only to look into exclusive disease specific changes, but more importantly to uncover potential common molecular pathogenic mechanisms that could be targeted for therapeutic gain. Surprisingly, no dysregulated gene that passed our selection criteria was found in common across all 6 diseases using our primary method of analysis. However, 61 dysregulated genes were shared when comparing five and four diseases. Our analysis indicates firstly the involvement of common neuronal homeostatic, survival and synaptic plasticity pathways. Secondly, we report changes to immunoregulatory and immunomodulatory pathways in all diseases. Our secondary method of analysis confirmed significant up-regulation of a number of genes in diseases presenting degeneration and showed that somatostatin was downregulated in all 6 diseases. The latter is supportive of a general role for neuroinflammation in the pathogenesis and/or response to neurodegeneration. Unravelling the detailed nature of the molecular changes regulating inflammation in the CNS is key to the development of novel therapeutic approaches for these chronic conditions.

Dataset Information

Synthesis, Insecticidal Activities and Mode of Action of Novel Imidazopyridine Mesoionic Derivatives Containing an Amido group

Publications

Synthesis, insecticidal activity, and mode of action of novel imidazopyridine mesoionic derivatives containing an amido group.

Similar Datasets

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