Mass spectrometry identification of PPARγ methylation sites
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Kai Huang
PROVIDER: PXD034929 | iProX | Mon Jun 27 00:00:00 BST 2022
REPOSITORIES: iProX
Publications
PRMT4 Facilitates White Adipose Tissue Browning and Thermogenesis by Methylating PPARγ.
Zhong Yi Y Wang Yilong Y Li Xiaoguang X Qin Haojie H Yan Shu S Rao Caijun C Fan Di D Liu Duqiu D Deng Fei F Miao Yanli Y Yang Ling L Huang Kai K Huang Kai K
Diabetes 20230801 8
Obesity is a global health threat, and the induction of white adipose tissue (WAT) browning presents a promising therapeutic method for it. Recent publications revealed the essential role of protein arginine methyltransferase 4 (PRMT4) in lipid metabolism and adipogenesis, but its involvement in WAT browning has not been investigated. Our initial studies found that the expression of PRMT4 in adipocytes was upregulated in cold-induced WAT browning but downregulated in obesity. Besides, PRMT4 over ...[more]
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