PHGDH Arginine Methylation by PRMT1 Promotes Serine Synthesis and Represents a Therapeutic Vulnerability in Hepatocellular Carcinoma

ABSTRACT: Serine synthesis is crucial for tumor growth and survival, but its regulatory mechanism in cancer remains elusive. Here, we found that R236 methylation of PHGDH promotes its activity and stimulates serine synthesis in hepatocellular carcinoma.

ORGANISM(S): Homo Sapiens

SUBMITTER: Canhua Huang  

PROVIDER: PXD035061 | iProX | Thu Jul 28 00:00:00 BST 2022

REPOSITORIES: iProX