Alteration of PFC proteome in MK-801 induced schizophrenia-like adolescent mice

ABSTRACT: Schizophrenia typically emerges in adolescence or early adulthood. Electrophysiological and several neurochemical changes have linked the GABA deficits to abnormal behaviors induced by NMDAR hypofunction. However, few studies have systematically investigated the molecular basis of GABA deficits, especially during adolescence. To address this issue, we transiently administrated MK-801 to mice on PND 10, which exhibited schizophrenia-relevant deficits in adolescence. Saline treated mice was served as controls. Cortical proteomics was performed on adolescent mice to investigate the proteome alteration.

ORGANISM(S): Mus Musculus

SUBMITTER: Donghong Cui  

PROVIDER: PXD035089 | iProX | Tue Jul 05 00:00:00 BST 2022

REPOSITORIES: iProX