Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus
SUBMITTER: Donghong Cui
PROVIDER: PXD035089 | iProX | Tue Jul 05 00:00:00 BST 2022
REPOSITORIES: iProX
Xue Ting T Wang Xiaodan X Hu Ying Y Cheng Ying Y Li Han H Shi Yuan Y Wang Lijun L Yin Dongmin D Cui Donghong D
Brain sciences 20221015 10
The brain is susceptible to perturbations of redox balance, affecting neurogenesis and increasing the risks of psychiatric disorders. Thioredoxin-interacting protein (TXNIP) is an endogenous inhibitor of the thioredoxin antioxidant system. Its deletion or inhibition suggests protection for a brain with ischemic stroke or Alzheimer's disease. Combined with conditional knockout mice and schizophrenia samples, we aimed to investigate the function of TXNIP in healthy brain and psychiatric disorders, ...[more]