CDK9 binds and activates SGK3 to promote cardiac repair after injury via the GSK-3β/β-catenin pathway

ABSTRACT: SGK3 (threonine-protein kinase 3) is a functional kinase we identified previously with the capacity to promote cardiomyocyte proliferation and cardiac repair after myocardial infarction. However, the upstream signals regulating SGK3 are still unknown. Based on the quantitative proteomics data and pulldown assay, we identified cyclin-dependent kinase 9 (CDK9) as a novel therapeutic target in regeneration therapy.

ORGANISM(S): Mus Musculus

SUBMITTER: Liansheng Wang  

PROVIDER: PXD035187 | iProX | Sat Jul 09 00:00:00 BST 2022

REPOSITORIES: iProX