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TMT-based proteome and phosphoproteome profile of unilateral ureteral obstruction

ABSTRACT: TMT-based proteome and phosphoproteome sequencing technology was performed on normal or unilateral ureteral obstruction samples to explore the potential mechanism and identify valuable diagnostic and therapeutic targets.

ORGANISM(S): Mus Musculus

SUBMITTER: Cheng Wang

PROVIDER: PXD035286 | iProX | Wed Jul 13 00:00:00 BST 2022

REPOSITORIES: iProX

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An integrated proteomic and phosphoproteomic landscape of chronic kidney disease.

Sun Linxiao L Wang Cheng C Zhou Zhongjing Z Li Qiangqiang Q

Journal of proteomics 20241114

The prevalence of chronic kidney disease (CKD) is gradually rising worldwide. Patients often remain asymptomatic for an extended period, leaving them unaware of their condition, which can lead to progressing to end-stage renal disease and cause significant economic burden. Improved understanding of CKD pathogenesis can enhance early detection and facilitate advances in drug development. Here, we performed proteomic and phosphoproteomic analyses of the mouse unilateral ureteral obstruction model ...[more]

PMID: 39547397

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