Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: Canhua Huang
PROVIDER: PXD035287 | iProX | Fri Jul 29 00:00:00 BST 2022
REPOSITORIES: iProX
Wang Kui K Luo Li L Fu Shuyue S Wang Mao M Wang Zihao Z Dong Lixia L Wu Xingyun X Dai Lunzhi L Peng Yong Y Shen Guobo G Chen Hai-Ning HN Nice Edouard Collins EC Wei Xiawei X Huang Canhua C
Nature communications 20230223 1
Serine synthesis is crucial for tumor growth and survival, but its regulatory mechanism in cancer remains elusive. Here, using integrative metabolomics and transcriptomics analyses, we show a heterogeneity between metabolite and transcript profiles. Specifically, the level of serine in hepatocellular carcinoma (HCC) tissues is increased, whereas the expression of phosphoglycerate dehydrogenase (PHGDH), the first rate-limiting enzyme in serine biosynthesis pathway, is markedly downregulated. Inte ...[more]