PHGDH Arginine Methylation by PRMT1 Promotes Serine Synthesis and HCC Growth

ABSTRACT: Serine synthesis is crucial for tumor growth and survival, but its regulatory mechanism in cancer remains elusive. Phosphoglycerate dehydrogenase (PHGDH) is the first rate-limiting enzyme in serine biosynthesis pathway. Here, we analyzed immunoprecipitated PHGDH from human HEK293T cells by liquid chromatography tandem mass spectrometry (LC-MS/MS), and identified the potential interacting proteins of PHGDH.

ORGANISM(S): Homo Sapiens

SUBMITTER: Canhua Huang  

PROVIDER: PXD035287 | iProX | Fri Jul 29 00:00:00 BST 2022

REPOSITORIES: iProX