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The proteome landscape of human placentas for monochorionic twins with selective intrauterine growth restriction

ABSTRACT: In this study, we profiled the placental proteome of IUGR twins and normal cotwins from 6 monochorionic twin pairs with selective intrauterine growth restriction (sIUGR).

ORGANISM(S): Homo Sapiens

SUBMITTER: Yuan Wei

PROVIDER: PXD035369 | iProX | Fri Jul 15 00:00:00 BST 2022

REPOSITORIES: iProX

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The Proteome Landscape of Human Placentas for Monochorionic Twins with Selective Intrauterine Growth Restriction.

Meng Xin-Lu XL Yuan Peng-Bo PB Wang Xue-Ju XJ Hang Jing J Shi Xiao-Ming XM Zhao Yang-Yu YY Wei Yuan Y

Genomics, proteomics & bioinformatics 20230429 6

In perinatal medicine, intrauterine growth restriction (IUGR) is one of the greatest challenges. The etiology of IUGR is multifactorial, but most cases are thought to arise from placental insufficiency. However, identifying the placental cause of IUGR can be difficult due to numerous confounding factors. Selective IUGR (sIUGR) would be a good model to investigate how impaired placentation affects fetal development, as the growth discordance between monochorionic twins cannot be explained by conf ...[more]

PMID: 37121272

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