Proteomics

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Proteogenomic Characterization of MiT Family Translocation Renal Cell Carcinoma

ABSTRACT: Comprehensive proteogenomic analysis of Microphthalmia Transcription Factor (MiT) family translocation renal cell carcinoma (tRCC) tumor and normal adjacent tissues was performed to elucidate the molecular landscape of these tumors.

ORGANISM(S): Homo Sapiens

SUBMITTER: Chen Ding  

PROVIDER: PXD035377 | iProX | Wed Jul 20 00:00:00 BST 2022

REPOSITORIES: iProX

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Microphthalmia transcription factor (MiT) family translocation renal cell carcinoma (tRCC) is a rare type of kidney cancer, which is not well characterized. Here we show the comprehensive proteogenomic analysis of tRCC tumors and normal adjacent tissues to elucidate the molecular landscape of this disease. Our study reveals that defective DNA repair plays an important role in tRCC carcinogenesis and progression. Metabolic processes are markedly dysregulated at both the mRNA and protein levels. P  ...[more]

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