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Label-free quantitative proteome profile of unilateral ureteral obstruction in mouse kidney

ABSTRACT: Label-free proteome sequencing technology was performed on normal or unilateral ureteral obstruction samples to explore the potential mechanism.

ORGANISM(S): Mus Musculus

SUBMITTER: Cheng Wang

PROVIDER: PXD035380 | iProX | Sat Jul 16 00:00:00 BST 2022

REPOSITORIES: iProX

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Integrative transcriptomic and proteomic profile revealed inhibition of oxidative phosphorylation and peroxisomes during renal interstitial fibrosis.

Wang Cheng C Pan Zhuo Z Sun Linxiao L Li Qiangqiang Q

Journal of proteomics 20240229

Effective therapies of chronic kidney disease (CKD) are lacking due to the unclear molecular pathogenesis. Previous single omics-studies have described potential molecular regulation mechanism of CKD only at the level of transcription or translation. Therefore, this study generated an integrated transcriptomic and proteomic profile to provide deep insights into the continuous transcription-translation process during CKD. The comprehensive datasets identified 14,948 transcripts and 6423 proteins, ...[more]

PMID: 38431085

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