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Proteomic analysis of SLC39A1 in RCC cells

ABSTRACT: To investigate the role of SLC39A1 in renal cell carcinoma, we established OS-RC-2 cell lines in which were transfected with SLC39A1 overexpressed vectors and empty vectors. We then performed proteomic analysis using data obtained from LC-MS/MS of 3 pairs of OSRC-2 cells.

ORGANISM(S): Homo Sapiens

SUBMITTER: Xiao Dong

PROVIDER: PXD035469 | iProX | Wed Jul 20 00:00:00 BST 2022

REPOSITORIES: iProX

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Integrated analysis of transcriptomics, proteomics and metabolomics data reveals the role of SLC39A1 in renal cell carcinoma.

Yuan Yulin Y Liu Zimeng Z Li Bohan B Gong Zheng Z Piao Chiyuan C Du Yang Y Zhan Bo B Zhang Zhe Z Dong Xiao X

Frontiers in cell and developmental biology 20221103

Purpose: Accumulating evidence suggests that solute carrier family 39 member 1 (SLC39A1) conceivably function as a tumor suppressor, but the underlying mechanism in renal cell carcinoma (RCC) is poorly understood. Methods: OSRC-2 renal cancer cells were first transfected with SLC39A1 overexpressed vectors and empty vectors and then used in transcriptomics, proteomics, and metabolomics integrated analyses. Results: SLC39A1 significantly altered several metabolisms at transcri ...[more]

PMID: 36407113

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Integrated Analysis of Transcriptomics, Proteomics and Metabolomics Data Reveals the role of SLC39A1 in Renal Cell Carcinoma

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