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Temporal proteomics characterization of COVID-19 patient sera

ABSTRACT: We enrolled 37 SARS-CoV-2 positive patients including 17 short course (SC) COVID-19 patients (twice viral RNA detection negative over 24 hrs) and 20 COVID-19 long course (LC) COVID-19 patients. We also included 35 SARS-CoV-2 negative patients as control group. We collected 224 inactive serum samples from this cohort and their clinical data. For those Covid-19 patients, we included 37 patients with 2-9 weeks comparing with negative control patients and used tandem mass tag (TMT) based proteomics method to profile temporal proteomics change for this cohort.

ORGANISM(S): Homo Sapiens

SUBMITTER: Tiannan Guo

PROVIDER: PXD035471 | iProX | Tue Jul 26 00:00:00 BST 2022

REPOSITORIES: iProX

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Enhanced inflammation and suppressed adaptive immunity in COVID-19 with prolonged RNA shedding.

Tang Xiaohua X Sun Rui R Ge Weigang W Mao Tingting T Qian Liujia L Huang Chongquan C Kang Zhouyang Z Xiao Qi Q Luo Meng M Zhang Qiushi Q Li Sainan S Chen Hao H Liu Wei W Wang Bingjie B Li Shufei S Lin Xiaoling X Xu Xueqin X Li Huanzheng H Wu Lianpeng L Dai Jianyi J Gao Huanhuan H Li Lu L Lu Tian T Liang Xiao X Cai Xue X Ruan Guan G Xu Fei F Li Yan Y Zhu Yi Y Kong Ziqing Z Huang Jianping J Guo Tiannan T

Cell discovery 20220725 1

Little is known regarding why a subset of COVID-19 patients exhibited prolonged positivity of SARS-CoV-2 infection. Here, we found that patients with long viral RNA course (LC) exhibited prolonged high-level IgG antibodies and higher regulatory T (Treg) cell counts compared to those with short viral RNA course (SC) in terms of viral load. Longitudinal proteomics and metabolomics analyses of the patient sera uncovered that prolonged viral RNA shedding was associated with inhibition of the liver X ...[more]

PMID: 35879274

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