Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: Fang Wang
PROVIDER: PXD035611 | iProX | Fri Jul 29 00:00:00 BST 2022
REPOSITORIES: iProX
Gu Yinuo Y Hsu Alan Chen-Yu AC Zuo Xu X Guo Xiaoping X Zhou Zhengjie Z Jiang Shengyu S Ouyang Zhuoer Z Wang Fang F
Frontiers in immunology 20230116
Influenza A virus (IAV) infection leads to severe inflammation, and while epithelial-driven inflammatory responses occur <i>via</i> activation of NF-κB, the factors that modulate inflammation, particularly the negative regulators are less well-defined. In this study we show that A20 is a crucial molecular switch that dampens IAV-induced inflammatory responses. Chronic exposure to low-dose LPS environment can restrict this excessive inflammation. The mechanisms that this environment provides to s ...[more]