Ontology highlight
ABSTRACT:
ORGANISM(S): Mus <genus>
SUBMITTER: Xiong Ji
PROVIDER: PXD035866 | iProX | Tue Aug 09 00:00:00 BST 2022
REPOSITORIES: iProX
Li Yuanjun Y Huang Jie J Zhu Junyi J Bao Lijun L Wang Hui H Jiang Yongpeng Y Tian Kai K Wang Rui R Zheng Haonan H Duan WenJia W Lai Weifeng W Yi Xiao X Zhu Yi Y Guo Tiannan T Ji Xiong X
Molecular cell 20220915 20
RNA polymerase II (RNA Pol II) subunits are thought to be involved in various transcription-associated processes, but it is unclear whether they play different regulatory roles in modulating gene expression. Here, we performed nascent and mature transcript sequencing after the acute degradation of 12 mammalian RNA Pol II subunits and profiled their genomic binding sites and protein interactomes to dissect their molecular functions. We found that RNA Pol II subunits contribute differently to RNA ...[more]