Proteomics

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The pathogenesis of diabetic kidney disease

ABSTRACT: Research on the pathogenesis of diabetic nephropathy focuses on regional immune regulation, homeostasis regulation of glucose and lipid metabolism, epigenetic regulation, and immune-metabolic interactions.

ORGANISM(S): Mus Musculus

SUBMITTER: Fuwen Zuo  

PROVIDER: PXD036050 | iProX | Sat Aug 13 00:00:00 BST 2022

REPOSITORIES: iProX

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Publications

CCDC92 promotes podocyte injury by regulating PA28α/ABCA1/cholesterol efflux axis in type 2 diabetic mice.

Zuo Fu-Wen FW   Liu Zhi-Yong ZY   Wang Ming-Wei MW   Du Jun-Yao JY   Ding Peng-Zhong PZ   Zhang Hao-Ran HR   Tang Wei W   Sun Yu Y   Wang Xiao-Jie XJ   Zhang Yan Y   Xie Yu-Sheng YS   Wu Ji-Chao JC   Liu Min M   Wang Zi-Ying ZY   Yi Fan F  

Acta pharmacologica Sinica 20240116 5

Podocyte lipotoxicity mediated by impaired cellular cholesterol efflux plays a crucial role in the development of diabetic kidney disease (DKD), and the identification of potential therapeutic targets that regulate podocyte cholesterol homeostasis has clinical significance. Coiled-coil domain containing 92 (CCDC92) is a novel molecule related to metabolic disorders and insulin resistance. However, whether the expression level of CCDC92 is changed in kidney parenchymal cells and the role of CCDC9  ...[more]

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